agard@msg.ucsf.edu 415 476-2521 Ph 415 476-1902 Fax Medical Sciences Building, S-1057 513 Parnassus Avenue University of California San Francisco, CA 94143-0448

Dave Agard

• PhD awarded in Biological Chemistry by the California Institute of Technology, Pasadena, California
• Chair, Graduate Group in Biophysics, UCSF
• Howard Hughes Medical Investigator in Structural Biology
• Scientific Director, California Institute for Quantitative Biomedical Research
• Professor of Biochemistry & Biophysics and Pharmaceutical Chemistry, UCSF
• Executive Committee, Program in Bioengineering, UCSF
• Faculty, UCSF/UCB Joint Graduate Group in Bioengineering
• Faculty and Executive Committee, UCSF Program in Bioengineering

The Agard Lab

The Macromolecular Structure Group

Our laboratory has focused on elucidating the basic principles of macro-molecular and surpamolecular structure and function. At a cellular level we are using a broad combination of approaches ranging from cryo-EM tomography to x-ray crystallography to RNAi to uncover the mechanism of microtubule nucleation by the centrosome. Developing new imaging and image analysis methodologies is a key part of this research. At the molecular level, we are using alpha-lytic protease as a model system to discover the structural basis for kinetic stability and the role of dynamics in protein function. In addition, we are investigating the structure and mechanism of the Hsp90 class of molecular chaperones.

David Agard: Breaking the Boundaries of Biology
Spotlight Science, Mission Bay article

Link to PubMed for publications search

© Program in Bioengineering, University of California
1700 4th St. MC0775, San Francisco, CA 94158-2330
Ph: 415 514-9242 // Fax 415 476-6022

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